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Zoological Research
Year: 2009  |  Volume: 30  |  Issue: 2  |  Page No.: 178 - 184

Antibacterial Activity Investigation of Human Semenogelin I Derived Peptides

GAO Zhen-hua, ZHAO Hui, YU Guo-yu, ZHANG Yun, SHEN Ji-hong and LEE Wen-hui    

Abstract:

SgI-29 is a newly characterized antibacterial peptide derived from human semenogelin I. Using SgI-29 as model, 4 peptides with different length were synthesized. Physico-chemical characteristics and structure prediction of SgI-29 and its derived peptides were analyzed by software packages and helix-wheel plot. The antibacterial activities of SgI-29 and its derived peptides against Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 were determined. The structure-function relationship of SgI-29 and its derivatives was analyzed. Our results indicated that SgI-22 has the strongest antibacterial activities against the tested bacteria among the synthetic peptides and might be used as a good model for the structure optimization.

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