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Veterinary Research
Year: 2013  |  Volume: 6  |  Issue: 2  |  Page No.: 32 - 38

Assessment of Modulations in Gluconeogenesis During Extreme Environmental Temperatures in Marwari Goat from Arid Tracts

A. Sharma, N. Kataria, N. Arya, M. Mathur, R. Maan, A. Joshi, Abhimanu, L.N. Sankhala, T. Bhati and A.K. Kataria    

Abstract: A study was conducted to assess modulations in gluconeogenesis in Marwari goat of both sexes ageing 6 months to 4.5 years during moderate, hot and cold environmental temperature periods. Liver samples were collected to determine Phosphoenolpyruvate Carboxykinase (PEPCK), Glucose-6-Phosphatase (Glc-6-Pase), Aspartate amino Transferase (AST) and Alanine Aminotransferase (ALT) enzymes. Moderate mean values of liver tissue PEPCK, Glc-6-Pase, AST and ALT were 562.00±7.25 U g-1, 160.00±4.25 mU g-1, 3.6±0.02 U g-1 and 2.6±0.01 U g-1, respectively. The mean values were significantly (p≤0.05) higher during hot and cold environmental temperatures in comparison to moderate mean value in each case. The sex and age effects were significant (p≤0.05) in all the environmental temperatures for all the four enzymes and pattern of variation was similar. The mean values were significantly (p≤0.05) higher in female animals than male animals. Age effect showed a significant (p≤0.05) increase in the mean values being highest in the animals of 2-4.5 years of age. Variation in the activities of all the enzymes studied clearly indicated the greater effect of hot environmental temperature on the modulation of gluconeogenesis. Hot period related change was maximum in the activity of PEPCK (4.29 fold) followed by Glc-6-Pase (3.5 fold), ALT (2.92 fold) and AST (2.38 fold). PEPCK and Glc-6-Pase are important enzymes of gluconeogenesis. Enhanced activities of these two enzymes showed adaptive response to combat the stress of environmental temperature through increased glucose production.

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