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Trends in Medical Research
Year: 2020  |  Volume: 15  |  Issue: 1  |  Page No.: 22 - 28

Dennettia tripetala Extracts Up-regulate Haematopoiesis against Carbon Tetrachloride Toxicity

Sylvia Oghogho Omage and Kingsley Omage    

Abstract: Background and Objective: The use of Dennettia tripetala in ethnomedicine to manage pain, inflammation and fever have been attributed to its analgesic effects. In this study, we evaluated the effect of Dennettia tripetala extracts on hematopoiesis against carbon tetrachloride-induced toxicity. Materials and Methods: Thirty Wistar experimental rats were weighed and randomized into six groups of five rats each. The rats were treated as described below in strict accordance with the NIH guidelines for the care and use of laboratory animals. Results: Administration of aqueous extract of Dennettia tripetala and subsequently carbon tetrachloride resulted in significant (p<0.05) increases in white blood cell count, percentage monocytes, percentage granulocytes and decreases in percentage Lymphocytes. Administration of the ethanolic extract and subsequently carbon tetrachloride resulted in significant (p<0.05) increases in white blood cells, percentage monocytes and granulocytes. Administration of the 250 mg kg1 with carbon tetrachloride resulted in significant (p<0.05) increases in red blood cells and haemoglobin while the 1000 mg kg1 ethanolic Dennettia tripetala extract alone caused Hematocrit and mean corpuscular volume to increase and mean corpuscular hemoglobin concentration to decrease significantly. Conclusion: Dennettia tripetala extracts at low doses up-regulated hematopoiesis which possibly prevented the harmful effects of carbon tetrachloride.

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