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Trends in Medical Research
Year: 2017  |  Volume: 12  |  Issue: 1  |  Page No.: 26 - 31

Levels of Trace Elements and Antioxidant Vitamins in Type 2 Diabetic Patients in Ile-Ife, Nigeria

O.F. Fagbohun, B. O. Emma-Okon, F. K. Agboola, B. A. Kolawole, O. H. Onakpoya and T.O. Odewole    

Abstract: Background: Levels of Zn, Cu, Mg, vitamin E and vitamin C were measured in 65 Nigerian diabetic subjects with and without micro vascular complications and compared with controls, in order to ascertain their association with the disease and its complications. Methods: Fasting blood glucose, glycated hemoglobin, Zn, Cu, Mg, vitamin E and vitamin C were assayed according to standard procedures. Statistical analysis was carried out using SPSS version 17.0. Results: Mean values of Zn, Mg and vitamin E were significantly higher (p<0.05) in control groups than diabetic subjects. The Zn levels correlated negatively with fasting blood glucose (p = 0.000, R = -0.443) and glycated hemoglobin (p = 0.030, R = -0.269) while Mg and vitamin E correlated negatively with fasting blood glucose (p = 0.000. R = -0.405 and p = 0.000, R = -0.524, respectively). The Zn, Mg and vitamin E levels correlated positively with each other. Diabetic subjects with retinopathy and nephropathy had significantly lower levels of vitamin E than others. Conclusion: Alterations in trace elements and vitamin status were observed in Nigerian diabetes mellitus subjects. The pattern differs from previous studies in respect of Cu and vitamin C levels. The alterations appear to be more as a result of diabetes itself, rather than being involved in the progression of the disease.

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