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Trends in Medical Research
Year: 2009  |  Volume: 4  |  Issue: 3  |  Page No.: 42 - 48

Impact of Glycerol, Mannitol, Neurotol and Neurotol Plus Administration in Alcohol Induced Ischemic Rat Model

A. Soni, M. Chaudhary, V.K. Dwivedi, S.M. Shrivastava and R. Sehgal    

Abstract: The aim of the present study was to evaluate the effect of various treatment of glycerol, mannitol, neurotol and neurotol plus on xanthine oxidase, adenylate kinase activities and MDA levels in alcohol induced ischemic rat model. Twenty Wistar rats (weighing 100- 200 g) were divided into four groups, glycerol treated group (20%), mannitol treated group (10%), fixed dose combination of glycerol (10%)+ mannitol (20%) (Neurotol) treated group and neurotol plus treated group (glycerol (10%)+mannitol (10%)). A significant decrease in xanthine oxidase activity, adenylate kinase activity and MDA levels were observed on treatments but decrease was maximum in neurotol plus treated groups suggesting that it has better free radical scavenging activity than glycerol, mannitol and neurotol.

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