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Trends in Medical Research
Year: 2009  |  Volume: 4  |  Issue: 3  |  Page No.: 35 - 41

Molecular Analysis of RAPD-PCR Genomic Patterns in Age Related Acute Myeloid Leukemia

Mohammed A. Ibrahim, N. Saleh, Khalida M. Mousawy, N. Al-Hmoud, E. Archoukieh, Haithum W. Al-Obaide and Mohannad M. Al-Obaidi    

Abstract: In this study the molecular genomic polymorphism of age related acute myeloid leukemia was analyzed by twenty one arbitrary primers of decamer oligonucleotides to investigate the genetic polymorphisms. Two categories of RAPD primers were identified, according to their ability to amplify genomic DNA. Thirteen primers were found unable to amplify genomic DNA of acute myeloid leukemia patients. On the other hand, eight primers were able to amplify genomic DNA and were divided into two subgroups, first group showed monomorphic DNA fragments, whereas the second one gave polymorphic bands. One of the polymorphic amplifying primers showed unique patterns of amplified DNA fragments in the genomic DNA of age related acute myeloid leukemia.

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