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Trends in Medical Research
Year: 2009  |  Volume: 4  |  Issue: 2  |  Page No.: 30 - 34

Comparative Evaluation of Fixed Dose Combination of Ofloxacin and Ornidazole Against Some Aerobic Bacteria

S.M. Shrivastava, S. Kumar and M. Chaudhary    

Abstract: The present study is undertaken to evaluate the antimicrobial properties of a new Fixed Dose Combination (FDC) of Ofloxacin Ornidazole for infusion against some aerobic bacteria in comparison with Ofloxacin and Ornidazole individually. Antibiotic Susceptibility Test (AST) and Minimum Inhibitory Concentration (MIC) of FDC of Ofloxacin Ornidazole, Ofloxacin and Ornidazole for P. aeruginosa, S. aureus, E. coli, K. pneumoniae, S. epidermis and MRSA were determined by disc method and broth micro dilution method. In Antimicrobial Susceptibility Test, lytic zone of combination was found to be more than Ofloxacin or Ornidazole alone in all microbial strains under study. The MIC value of FDC of Ofloxacin Ornidazole was found to be higher than both Ofloxacin and Ornidazole. The data suggests that fixed dose combination of Ofloxacin and Ornidazole can be a good option for use in mixed microbial infection of aerobic bacteria, anaerobic bacteria and pathogenic protozoans.

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