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Trends in Medical Research
Year: 2008  |  Volume: 3  |  Issue: 1  |  Page No.: 10 - 15

Analgesic and Anti-Inflammatory Screening of Newbouldia laevis Flower in Rodents

H. Usman, A.H. Yaro and M.M. Garba    

Abstract: Analgesic and anti-inflammatory effects of the ethanolic flower extract of Newbouldia laevis were studied in rodents. Investigations were carried out on acetic acid-induced writhing in mice and carrageenan-induced hind paw oedema in rats. The results showed that the ethanol extract possessed significant (p< 0.001) anti-nociceptive activity between 50 and 200 mg kg-1 intraperitoneally (i.p.) in mice and also dose dependent anti-inflammatory activity between 50 and 200 mg kg-1 (i.p.) in rats. These effects were compared favourably with that expressed by ketoprofen (10 mg kg-1 i.p). From the results obtained, although relatively toxic the extract exhibited highest anti-nociceptive and anti-inflammatory activities at the dosage of 200 mg kg-1 (i.p.). These data corroborate with the traditional use of this plant in the treatment of rheumatic pain and other types of pain reported in traditional medicine.

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