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Trends in Medical Research

Year: 2007  |  Volume: 2  |  Issue: 1  |  Page No.: 51 - 56

Some Lysosomal Enzyme Profiles in Children with Nephroblastoma: The Effect of Nephrectomy

Donatien Gatsing, H. Ibrahim Garba, Roseline Aliyu, H. Abiodun Adebayo, P. Obekpa and I. Godwin Adoga

Abstract

The serum levels of some lysosomal enzymes-namely β-glucuronidase (EC 3.2.1.31), β-galactosidase (EC 3.2.1.23) and acid phosphatase (EC 3.1.3.2)-were measured in controls, pre-operative and post-operative nephroblastoma patients. β-glucuronidase activity showed a significant (p<0.05) increase before surgical intervention, followed by significant (p<0.05) decreases 24 h, 72 h and 7 days after operation. The activities of β-galactosidase and acid phosphatase showed no significant (p>0.05) changes before and after surgical intervention. These data indicate that nephroblastoma and surgery may have a marked effect on the serum levels of some lysosomal enzymes.

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