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Trends in Medical Research
Year: 2007  |  Volume: 2  |  Issue: 3  |  Page No.: 135 - 141

Biochemical and Histopathological Studies of Herbal Cream Against UV Radiation Induced Damage

M.S. Ashawat, Saraf Shailendra and Saraf Swarnlata    

Abstract: The present study was to prepare and characterized herbal cosmetic cream comprising extracts of G. glabra, C. longa (roots), seeds of P. corlifolia, C. tora, A. catechu, P. granatum, fruits of E. officinale, leaves of C. asiatica, dried bark of C. zeylanicum and fresh gel of A. vera for the protection of skin against UV induced aging. To investigate the antioxidant activity of cream formulations the UV radiation induced oxidative stress was generated in rats and protective effects were measured after topically applied (2 mg cm-2 day-1) for thirty days. The level of antioxidant enzymes (catalase and superoxidedismutase), non-enzyme components (ascorbic acid level and melanodialdehyde) and ascorbic acid were estimated. The structural changes were observed by using histological techniques. Results showed significant improvement in superoxidedismutase, catalase, total protein and ascorbic acid level with decreased melanodialdehyde level. The treatment with such herbal extracts containing creams could be utilized for the protection of photo induced intrinsic oxidative stress as well as structural alterations in skin.

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