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Turkish Journal of Medical Sciences
Year: 2011  |  Volume: 41  |  Issue: 5  |  Page No.: 761 - 768

Lipid profile alterations and oxidative stress in patients with preeclampsia: role of black tea extract on disease management

Ekambaram PADMINI and Munuswamy USHA RANI    

Abstract: Aim: To investigate the lipid profile and susceptibility of low-density lipoprotein (LDL) to oxidation in preeclamptic women and to correlate the results with preeclampsia risk in the absence and presence of black tea extract (BTE). Preeclampsia is a disorder of human pregnancy characterized by altered endothelial function, secondary to oxidative stress. Materials and methods: Lipid profile levels and oxidative stress status were investigated in the cord blood of normotensive and preeclamptic patients. LDL susceptibility to oxidation was also monitored in the absence and presence of BTE to examine its protective role. Results: A significant alteration in lipid parameters and enhanced oxidative stress was observed in patients with preeclampsia compared to control subjects. Increased susceptibility of LDL to oxidation in the preeclamptic group was reduced during incubation with BTE. Conclusion: The present study demonstrates a hyperlipidemic and oxidative environment in preeclamptic patients. The protective role of BTE against LDL oxidation suggests its recommendation as a supplement for preeclamptic patients, which may provide protection against oxidative modification of LDL and endothelial dysfunction.

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