Asian Science
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Abstract: Aim: To investigate the lipid profile and susceptibility of low-density lipoprotein
(LDL) to oxidation in preeclamptic women and to correlate the results with preeclampsia
risk in the absence and presence of black tea extract (BTE). Preeclampsia is a
disorder of human pregnancy characterized by altered endothelial function, secondary
to oxidative stress. Materials and methods: Lipid profile levels and oxidative
stress status were investigated in the cord blood of normotensive and preeclamptic
patients. LDL susceptibility to oxidation was also monitored in the absence and
presence of BTE to examine its protective role. Results: A significant alteration
in lipid parameters and enhanced oxidative stress was observed in patients with
preeclampsia compared to control subjects. Increased susceptibility of LDL to
oxidation in the preeclamptic group was reduced during incubation with BTE. Conclusion:
The present study demonstrates a hyperlipidemic and oxidative environment in preeclamptic
patients. The protective role of BTE against LDL oxidation suggests its recommendation
as a supplement for preeclamptic patients, which may provide protection against
oxidative modification of LDL and endothelial dysfunction.