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Turkish Journal of Medical Sciences
Year: 2011  |  Volume: 41  |  Issue: 5  |  Page No.: 755 - 759

Postoperative atrial fibrillation, oxidative stress, and inflammation

Mehmet OZAYDIN    

Abstract: Postoperative atrial fibrillation is the most common complication of cardiac surgery. It is associated with increased complication rates. Recent trials have suggested that inflammation and oxidative stress have key roles in the pathophysiology of atrial fibrillation. Current evidence evaluating the use of antiinflammatory and antioxidant agents, including statins, corticosteroids, N-acetylcysteine, vitamin C, and fish oil, to prevent postoperative atrial fibrillation is promising. However, larger randomized, controlled trials comparing different dose regimens are needed.

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