Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Turkish Journal of Medical Sciences
Year: 2010  |  Volume: 40  |  Issue: 5  |  Page No.: 687 - 692

Serum prolidase activity in patients with degenerative and rheumatic heart valve diseases

Murat Bulent RABUS, Recep DEMIRBAG, Yusuf SEZEN, Mehmet TASAR, Abdullah TASKIN, Nurten AKSOY, Kaan KIRALI and Cevat YAKUT    

Abstract: Aim:It is known that renin-angiotensin system, inflammation, signaling pathways, and genetic predisposition play a major role in the pathogenesis of heart valve disease. Scarring and collagen deposition in the valves and destruction of myocytes may result from the combined effects of rheumatic and degenerative process in heart valve diseases. Prolidase plays an important role in collagen metabolism, matrix remodeling and cell growth. The aim of the study was to comparatively assess the serum prolidase activity in rheumatic and degenerative heart valve diseases. Materials and methods: The study included 26 patients who had undergone valve replacement due to rheumatic etiology (Group I), 24 patients who had undergone valve replacement due to degenerative etiology (Group II) and 20 healthy volunteers (Group III). Prolidase activity was determined in all subjects. High sensitive C-reactive protein and white blood cell count were studied in only valve patients. Results:Prolidase activity was significantly greater in control group than in patients group (51.23.± 5.9 U/L vs. 39.40 ± 4.6 U/L, respectively; P < 0.001). There was no statistically significant difference between Group I and Group II (P = 0.721). No correlation was detected between serum prolidase activity and severity of valve disease (P > 0.05). Conclusion: These results suggested that rheumatic and degenerative heart valve diseases seem to be associated with decreased serum prolidase activity.

View Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

No Article Found
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility