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Turkish Journal of Medical Sciences
Year: 2010  |  Volume: 40  |  Issue: 1  |  Page No.: 115 - 119

Plasma vitamin A and E levels in patients with gastroesophageal cancer in Eastern Anatolia

Omer YILMAZ, Hakan DURSUN, Sait KELES, Arif YILMAZ and Nihat OKCU    

Abstract: Aim:Gastrointestinal system (GIS) cancers account for a significant percentage of morbidity and mortality worldwide. Free radicals may play a role in the development of GIS cancers at various stages. The goal of this study was to analyze the relationship between gastroesophageal cancer and plasma levels of vitamin A and vitamin E, a significant part of antioxidant defense.
Materials and methods: Twenty-six patients with gastroesophageal cancer diagnosed by endoscopy and histopathologic examination and 26 healthy volunteer subjects were included in this study. Plasma vitamin A and vitamin E levels were determined by high-performance liquid chromatography using a commercially available kit.
Results: Plasma vitamin A and vitamin E levels were significantly lower in the gastroesophageal cancer group (1.39 ± 0.137 Ámol/L and 13.5 ± 1.29 μmol/L, respectively) than in the control group (2.79 ± 0.163 μmol/L and 21.29 ± 2.58 μmol/L, respectively). The difference was significant at P < 0.001 for vitamin A, and P < 0.05 for vitamin E values. However, we could not detect any significant difference in plasma vitamin A and vitamin E levels when the stage of the disease was taken into consideration (P > 0.05).
Conclusion: Decreased plasma vitamin A and vitamin E levels, as important antioxidant components, may be contributory in the development of gastroesophageal cancer. Diets rich in antioxidant vitamins may be protective against the development of upper gastrointestinal tract disease.

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