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Turkish journal of chemistry
Year: 2010  |  Volume: 34  |  Issue: 6  |  Page No.: 945 - 952

Biotransformation of danazol by Fusarium solani and FGibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products

AZIZUDDIN and Muhammad Iqbal CHOUDHARY    

Abstract: Biotransformation of danazol (17β-hydroxy-17 α-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17β-hydroxy-2-(hydroxymethyl)-17α -pregn-4-en-20-yn-3-one (2) and 17β-hydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.

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