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Turkish journal of chemistry
Year: 2010  |  Volume: 34  |  Issue: 1  |  Page No.: 57 - 65

Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Deniz S. DOGRUER, Solen URLU, Tijen ONKOL, Berrin OZCELİK and M. Fethi SAHIN    

Abstract: Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 μ g/mL) and E. coli (MIC ranging from 4 to 16 μ g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 μ g/mL.

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