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Turkish journal of chemistry
Year: 2008  |  Volume: 32  |  Issue: 3  |  Page No.: 365 - 374

Synthesis of Some New 4-oxo-4H-Chromene Derivatives Bearing Nitrogen Heterocyclic Systems as Antifungal Agents

Tarik EL-SAYED ALI, Salah ABDEL-AGHFAAR ABDEL-AZIZ, Hafez METWALI EL-SHAAER, Faten ISMAIL HANAFY and Ali ZAKY EL-FAUOMY    

Abstract: Some new 4-oxo-4H-chromone derivatives bearing nitrogen heterocyclic systems were achieved by treatment of 3-[(4-aminophenylimino) methyl]-6-chloro-4-oxo-4H-chromene (2) with some aldehydes, cyclic oxygen, and halogen compounds, followed by heterocyclization. Significant antifungal activities were observed for some of the prepared compounds. Structures of all products were confirmed by elemental analysis, IR, 1H-NMR, and mass spectra.

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