Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Turkish journal of chemistry
Year: 2008  |  Volume: 32  |  Issue: 2  |  Page No.: 205 - 215

Synthesis, Spectroscopic and Biological Investigation of Cyclic Octapeptide: Cherimolacyclopeptide G

Rajiv DAHIYA    

Abstract: A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carboxyl and amino terminals followed by cyclization of the linear peptide segment. The structure was elucidated by IR, 1H-NMR, 13C-NMR, FAB MS spectral data, and elemental analyses. The newly synthesized cyclopeptide was also evaluated for its antimicrobial, anthelmintic, and cytotoxic activities and found to exhibit potent anthelmintic and cytotoxic activity against earthworms, Megascoplex konkanensis, Pontoscotex corethruses, and Eudrilus species, and Dalton’s lymphoma ascites (DLA) and Ehrlich`s ascites carcinoma (EAC) cell lines. In addition, compound 8 possessed moderate antimicrobial activity against the pathogenic fungus Candida albicans and gram-negative bacterium Pseudomonas aeruginosa.

View Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility