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Trends in Applied Sciences Research
Year: 2011  |  Volume: 6  |  Issue: 4  |  Page No.: 400 - 409

Prediction of in vitro Drug Release Mechanisms from Extended Release Matrix Tablets using SSR/R2 Technique

J. Singh, S. Gupta and H. Kaur    

Abstract: Drug release from polymers may be erosion or diffusion based or combination of these processes. Various equations and models are available for relating drug release. Most of the decisions are made on basis of similarity of original and predicted release profiles (predicted by fitting release data in various models or equations). In this study, decision for release pattern has been made on basis of SSR/R2 for model drug ofloxacin from laboratory developed Extended Release (ER) matrix tablets. Three batches A, B, C having HPMC, sodium alginate and 50:50% mixture of HPMC:sodium alginate were prepared. The USP Dissolution apparatus 2 was used for ofloxacin release and swelling-erosion studies of different batches in SGF, buffer of pH 6.2 and SIF. The batch C, ofloxacin matrix tablet composition was finalised on basis of <30% release within 1 h in SGF, >85% release upto 8 h in SIF and conformity to shape of profile within 1-7 h dissolution in buffer of pH 6.2. Instead of use of SSR and R2 on individual basis, SSR/R2 expressed ofloxacin release mechanisms in good agreement to physically observed swelling-erosion behaviors of matrix tablets in all pH conditions.

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