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Trends in Applied Sciences Research
Year: 2009  |  Volume: 4  |  Issue: 2  |  Page No.: 107 - 115

Methoxy Poly (Ethylene Glycol)-b-Poly (D, L-lactide) Films for Controlled Release of Ibuprofen

T. Phromsopha and Y. Baimark    

Abstract: Biodegradable films of methoxy poly (ethylene glycol)-b-poly (D, L-lactide) diblock copolymers (MPEG-b-PDLL) containing drug were prepared by solution casting of MPEG-b-PDLL and drug in dichloromethane. Ibuprofen was used as a poorly-water soluble model drug. Influences of MPEG-b-PDLL/drug ratio and film thickness on ibuprofen-loaded film characteristics and drug release behaviors were investigated. The hydrogen bonding between MPEG-b-PDLL and drug were detected from FTIR analysis. From FTIR and differential scanning calorimetric results indicated that the ibuprofen was well distributed throughout the MPEG-b-PDLL film matrices. The drug release rates increased as the drug ratio increased and the film thickness decreased. The drug release from the films occurred by drug diffusion mechanism.

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