Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Trends in Applied Sciences Research
Year: 2009  |  Volume: 4  |  Issue: 2  |  Page No.: 107 - 115

Methoxy Poly (Ethylene Glycol)-b-Poly (D, L-lactide) Films for Controlled Release of Ibuprofen

T. Phromsopha and Y. Baimark    

Abstract: Biodegradable films of methoxy poly (ethylene glycol)-b-poly (D, L-lactide) diblock copolymers (MPEG-b-PDLL) containing drug were prepared by solution casting of MPEG-b-PDLL and drug in dichloromethane. Ibuprofen was used as a poorly-water soluble model drug. Influences of MPEG-b-PDLL/drug ratio and film thickness on ibuprofen-loaded film characteristics and drug release behaviors were investigated. The hydrogen bonding between MPEG-b-PDLL and drug were detected from FTIR analysis. From FTIR and differential scanning calorimetric results indicated that the ibuprofen was well distributed throughout the MPEG-b-PDLL film matrices. The drug release rates increased as the drug ratio increased and the film thickness decreased. The drug release from the films occurred by drug diffusion mechanism.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility