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Trends in Applied Sciences Research
Year: 2008  |  Volume: 3  |  Issue: 1  |  Page No.: 90 - 96

Antimicrobial Activity of Trichilia priedreana Leaves Against Selected Pathogenic Organisms

D.J. Arotupin, K.O. Awojobi and R.A.O. Gabriel-Ajobiewe    

Abstract: The ethanolic, methanolic and water extracts of dried powdered leaves of Trichilia priedreana (Meliaceae) were tested for their antimicrobial activity on selected clinical pathogenic organisms. This was carried out using agar well diffusion method. The methanolic extract was found to be the most potent, followed by the ethanolic extract, while water extract was the least potent. Staphylococcus aureus and Proteus mirabilis were highly susceptible to the methonolic and ethanolic extracts, while all the fungi, Aspergillus flavus, A. niger and Candida albicans were susceptible to the extracts with C. albicans being the most susceptible showing higher zones of inhibition. Extracts of T. priedreana were found to be more active than the standard commercial antibiotics. The MIC of the extracts varied from 1.563 to 12.5 mg mL-1 for the bacteria and 6.25 to 12.5 mg mL-1 for the fungi. The pH values of the extracts ranged from 4.40 to 6.64. Phytochemical screening showed the presence of alkaloids, phlobatannins, tannins and saponins. The yields from the plant leaves are very adequate possessing antimicrobial components comparable to commercial antibiotics, hence can be a good source of agents for chemotherapy.

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