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Research Journal of Pharmacology
Year: 2016  |  Volume: 10  |  Issue: 2-6  |  Page No.: 6 - 12

Cynodon dactylon Rhizome Extract Decreases the Cardiovascular Biomarkers (Cardiac Troponin I and Homocysteine) and Adenosine Deaminase Activity in Alloxan-Induced Diabetes Mellitus in Cats

Kurosh Amanzadeh, Kaveh Azimzadeh and Ali Hayatrouhi    

Abstract: The aim of this study was to evaluate the plasma changes of cardiac Troponin I level (cTnI), Homocysteine (Hcy) and the activity of Adenosine Deaminase (ADA) in the alloxan-induced diabetes mellitus and following administration of pure Cynodon dactylon extract in the diabetic cats. Diabetes Mellitus (DM) is known as a metabolic disease which is followed by different blood and tissue complications. In this study, the cTnI, Hcy and ADA activity was measured in diabetic group after 3 months administration of Cynodon dactylon extract in three 150, 300 and 450 mg kg–1 doses. The significant increase (p<0.01) in cTnl, Hcy and ADA parameters in diabetic (positive control) group was determined in comparison to the control group (negative control) and a significant decrease of those ones (p<0.01) in the 450 mg kg–1 dose of Cynodon dactylon in comparison to the diabetic and control group. In conclusion, firstly heart damage occurs in diabetic cats which needs more attention to this issue in DM complications management and secondly the Cynodon dactylon extract extremely influences the reduction of above-mentioned parameters and usage of dried powder of Cynodon dactylon in the food of the diabetic cats may play important role in the cardiovascular health and increasing the glucose consumption by cells.

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