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Research Journal of Pharmacology
Year: 2007  |  Volume: 1  |  Issue: 4  |  Page No.: 79 - 83

In vivo Antiplasmodial Activity and Acute Toxicity of the Fraction of the Garcinia parvifolia Miq. Stem Bark

Syamsudin, S. Wahyuono, S. Tjokrosonto and Mustofa    

Abstract: The study of in vivo antiplasmodial activity and acute toxicity of the active fraction of Garcinia parvifolia Miq has been conducted. The fraction was obtained by maceration of n-hexane extract with methanol. A standard 4-day test on P. berghei infected Swiss mice was used to evaluate the in vivo antiplasmodial activity after an oral administration of the fraction in series dose of 25-200 mg kg 1 BW once daily for 4 consecutive days. The in vivo antiplasmodial activity was expressed by the dose inhibiting 50% of parasite growth (ED50). Acute toxicity was evaluated in Swiss mice after oral administration of the active fraction in series dose of 2000-8000 mg kg 1 BW. The acute toxicity was expressed by the dose leading 50% deaths (LD50). The results showed that the active fraction of G. parvifolia Miq was active against P. berghei in mice with an ED50 of 74.45 mg/kg BW/d. In addition, the active fraction was also relatively safe as expressed by the LD50 of 8.000 mg kg 1 BW.

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