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Research Journal of Animal Sciences
Year: 2014  |  Volume: 8  |  Issue: 3  |  Page No.: 24 - 29

Evaluation of Prophylactic Cloprostenol and E. coli LPS Treatment Against Endometritis in Dairy Cows and Buffaloes

B.U. Wakayo, P.S. Brar, S. Prabhakar and A.K. Arora    

Abstract: A field trial was conducted to evaluate immunomodulatory prophylactic modalities against persistent uterine infection in 24 Murrah buffaloes and 21 cross-bred Holstein Frisian cows. All animals were treated with intramuscular ceftiofur sodium for 5 days post-calving. On or after 7th day animals were randomly assigned to either; intrauterine normal saline (controls = 15), intrauterine E. coli LPS (LPS = 15) or intramuscular Cloprostenol (cloprostenol = 15). Endometritis was Determined at 35 days in Milk (DIM) and estrus, breeding and conception were monitored until 120 DIM. Clinical Endometritis (CE) occurred in 6 (60%), 3 (30%) and 2 (20%) assisted calving animals assigned to control, cloprostenol and LPS groups, respectively (p = 0.196). All but one assisted calving animals had cytological uterine inflammation at 35 DIM. Among normal calving animals 1 (20%), 3 (60%) and 4 (80%) of those in control, LPS and cloprostenol groups, respectively showed cytological uterine inflammation (p = 0.415). Meanwhile, 93.3, 86.7 and 66.7% of the LPS, Cloprostenol and Control group animals were observed in heat within 120 DIM (p = 0.229). Rate of conception within 120 DIM was similar 3 (37.5) among treatment groups in buffaloes but varied in cows from a high of 3 (42.9) in control group to a low of 0 in Cloprostenol group. The application of early puerperal immunostimulatory treatment with cloprotenol or E. coli LPS for prevention of endometritis and sub-fertility appears limited requires further validation.

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