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Research Journal of Animal Sciences
Year: 2007  |  Volume: 1  |  Issue: 1  |  Page No.: 49 - 52

Immune Responses of Sheep Vaccinated with Combined Anthrax and Capripox Vaccine

Abbas Mohamed Ahmed, M.M. Mukhtar, A.M. ELHussein, Tageldin A.M. Nour and M.A. Fadol    

Abstract: The combined anthrax and sheep pox vaccine was prepared in a lyophilized form containing the recommended doses of both sheep and goat strain 0240 pox and anthrax live spore vaccine. Immunization of sheep with this vaccine revealed a considerable immune response when detected with immunocapture Enzyme Linked Immunosorbent Assay (ELISA), indirect ELISA and with (3-(4, 5-dimethylthiazolyl-2) -2, 5-diphenyltetrazolium bromide) (MTT) lymphocytes proliferation assay. The difference in titers of antibodies raised against capripox virus antigen was significant, it was also significant for antibodies raised against crude Protective Antigen (cPA) and killed spore antigen. Phytohemagglutinin (PHA) revealed high Stimulation Index (SI) before vaccination but low one after vaccination while the SPPV antigen showed slight SI before vaccination and high SI after vaccination indicating cellular immune response to this antigen. Low SI of PHA after vaccination might be due antimitogenic effect of SPV antigens.

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