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Research Journal of Medical Sciences
Year: 2016  |  Volume: 10  |  Issue: 6  |  Page No.: 711 - 715

Evaluation of Protective Effects of N-Acetyl Cysteine and Vitamin C on Perioperative Renal Function in High-Risk Patients Undergoing Coronary Artery Surgeries, a Randomized Clinical Trial

Ali Karami, Saeed Reza Soltani, Pooya Vatankhah, Seyd Hedayatallah Akhlagh, Mansoor Masjedi and Masih Shafa    

Abstract: Perioperative renal failure is one of the major complications following coronary artery surgeries, leading to increased morbidity and mortality rates in patients; necessitating renal replacement therapy and longer hospital and ICU stay. Considering the antioxidative effects of N-Acetyl Cysteine (NAC) and vitamin C in decreasing inflammatory factors, this study was designed to evaluate and compare the protective effects of these two agents on renal function of high-risk patients undergoing coronary artery surgeries. This study was a randomized clinical trial research. Ninety patients undergoing cardiac bypass surgery, who were considered as high-risk for postoperative renal failure, were randomized into 3 groups. Group A received NAC, group B received NAC plus vitamin C and group C received Dextrose water 5% as placebo. The agents were administered during and 12 and 24 h after the operation. Serum creatinine levels one day before the operation and also on 1st, 2nd and 3rd days after the operation were recorded and compared. The results revealed no significant differences in serum creatinine levels between the three groups in any of the evaluated days. Based on the results of our study, administration of NAC or its combination with vitamin C does not affect the outcome of renal function in high-risk patients undergoing cardiac bypass surgery.

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