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Research Journal of Medical Sciences
Year: 2013  |  Volume: 7  |  Issue: 3  |  Page No.: 75 - 79

The Profiles of Lipid Peroxidation and Anti-Oxidant Activities in Gestational Diabetes Mellitus and Normal Pregnancies in Nigerian Population

Adetunji O. Adeniji and Dolapo P. Oparinde    

Abstract: To compare the lipid peroxidation and total antioxidant status in women with gestational diabetes mellitus and normal pregnancy in the environment. This was a 2 years, cross sectional case control study of 25 Gestational Diabetes Mellitus (GDM) and 75 matched normal pregnant women at Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol was reviewed and approved by the Institutional Ethical Review Committee and all participants gave their consent. The fasting serum of recruited patients were analysed for lipid peroxidation product Malondialdehyde (MDA) based on MDA reaction with Thiobarbituric Acid (TBA) with rapid, sensitive and specific Thiobarbituric Acid (TBA) assay while the Total Anti-oxidant Status (TAS) was determined using the capacity of the biological fluids to inhibit the production of Thiobarbituric Acid Reactive Substances (TBARS) from sodium benzoate under the influence of the free oxygen radicals derived from Fentonís reaction. The mean serum MDA was significantly higher in the GDM group (3.64 nmol mL-1) than the value recorded (1.33 nmol mL-1) in the control group (p<0.0001). Conversely, significantly lower mean TAS (0.34 vs. 0.66 nmol mL-1) was noticed in the GDM group (p<0.0001). The study showed significant increase in lipid peroxidation and failure of compensatory antioxidant functions in GDM Nigerian women.

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