Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Research Journal of Medical Sciences
Year: 2011  |  Volume: 5  |  Issue: 5  |  Page No.: 286 - 288

Polymorphism of Human (CTLA4) Gene and Insulin-Dependent Diabetes Mellitus Associated with Obesity in Iraqi Population

Shatha Ramadhan Zaidan    

Abstract: The cytotoxic T Lymphocyte-Associated Antigen 4 gene (CTLA4) encodes the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. The receptor protein is a specific T lymphocyte surface antigen that is detected on cells only after antigen presentation. Thus, CTLA4 is directly involved in both immune and autoimmune responses and may be involved in the pathogenesis of multiple T cell-mediated autoimmune disorders. In this research the work was to investigate whether this gene conferred susceptibility to IDDM in a Russian population. The researchers carried out family studies using two polymorphic markers at the CTLA4 gene locus: codon 17 dimorphism and the dinucleotide microsatellite in the 3' untranslated region. The Ala17 allele of the CTLA4 gene was preferentially transmitted from parents to diabetic offspring (p<0.0001) as shown by the combined Transmission/Disequlibrium Test (TDT) and Sib TDT (S-TDT) analysis.

Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility