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Research Journal of Medical Sciences
Year: 2008  |  Volume: 2  |  Issue: 2  |  Page No.: 57 - 60

SAnti-Diabetic Effect of Ethanolic Flower Extracts of Newbouldia laevis (Bignoniaceae) on Blood Glucose Levels of Streptozocin-Induced Diabetic Wistar Rats

Y. Tanko, M.A. Okasha, M.I.A. Saleh, A. Mohammed, M. Yerima, A.H. Yaro and A.I. Isa    

Abstract: This study was undertaken to evaluate the hypoglycemic effect of ethanolic flower extract of Newbouldia laevis on blood glucose levels of streptozocin-induced diabetes rats. Three doses of the extract (250, 500 and 1000 mg kg 1) were administered intraperitoneally. After 2 h of extract administration there was no significant change in the blood glucose levels in all the three doses of the extract administered. Also after 4, 8 and 24 h of extract administration there was a significant (p< 0.05) decrease in the blood glucose levels in doses of the extract administered. The preliminary phytochemical screening revealed the presence of cardiac glycosides, tannins, flavonoids and steroids. The median Lethal Dose (LD50) in rats was calculated to be 1264.9 mg kg 1 body weight. The ethanolic flower extract of Newbouldia laevis possess anti-diabetic effect in streptozocin induced in diabetic rats.

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