Hypoglycemic Activity of Aloe vera Powder and Gel Drink in Alloxan-induced Diabetic Rats
Background and Objective: Aloe vera leaves contain of flavonoid compounds which were used as an antioxidant. Previous research showed that the flavonoids of Aloe vera extracts could lower blood glucose. However, the use of Aloe vera extract is unfavorable. Therefore, processing of Aloe vera into an acceptable product such as a powder or Aloe vera gel drink was necessary to be carried out. The purpose of this research was to evaluate the hypoglycemic activity of Aloe vera powder and gel drink. Materials and Methods: The antioxidative activity of Aloe vera products was analyzed by using the 1,1-Diphenyl-2-picrylhydrazyl and ferry thiocyanate methods and the hypoglycemic test was determined with the in vivo method using diabetic Wistar rats induced with alloxan 25 mg/200 g b.wt., as experimental animals. The rats were fed with a standard feed combined with Aloe vera powder or gel drink. The intake of fed was equivalent to 600 IU antioxidant standard of α-tocopherol. Results: The research showed that Aloe vera powder had high antioxidative activity shown by the Radical Scavenging Activity (RSA) which was 26.15% and the inhibition of lipid peroxidation was 44.17%, whereas Aloe vera gel drink were 21.96 and 5.63%, respectively. These result related to the hypoglycemic effect. Conclusion: Aloe vera powder and gel drink had hypoglycemic effect which indicated by a decrease in blood glucose from after four weeks, so these products appropriate for diabetics.
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