Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Research Journal of Medicinal Plants
Year: 2019  |  Volume: 13  |  Issue: 2  |  Page No.: 39 - 45

Antidiabetic Effect of Viburnum foetidum Bark in Cell Lines and Wistar Rats

Rita Maneju Sunday, Efere Martins Obuotor and Anil Kumar    

Abstract: Background and Objectives: Diabetes mellitus is a metabolic disease that is on the increase globally in recent years. Viburnum foetidum is a medicinal plant used in traditional medicine for the treatment of various diseases. In this study, the antidiabetic effect of Viburnum foetidum bark ethanolic extract (VFE) and ethanolic extract fractions (n-butanol, ethyl acetate and n-hexane) were evaluated using both in vitro (RIN-5F and HepG2 cells) and in vivo (glucose loaded [10 g kg1] and streptozotocin [60 mg kg1] induced diabetic Wistar rats) models. Materials and Methods: In the in vivo studies, 100, 200 and 400 mg kg1 Viburnum foetidum bark ethanolic extract and 200 mg kg1 of each extract fractions were administered to streptozotocin (60 mg kg1) induced diabetic Wistar rats. Non toxic mass value of Viburnum foetidum extract was used in the in vitro (0.625, 1.25 and 2.5 μg/100 μL) and in vivo (100, 200 and 400 mg kg1) studies. Results: Viburnum foetidum extract and extract fractions increased RIN-5F insulin secretion and HepG2 glucose uptake when compared with untreated cells. Whereas, in 21 days treated diabetic rats, the extracts caused a decrease in fasting blood glucose level, increase in serum insulin and serum α-amylase level when compared with the untreated rats. The ethyl acetate extract fraction at 200 mg kg1 exerted a more increase in RIN-5F cells insulin secretion, HepG2 cells glucose uptake, serum insulin and serum α-amylase level than other extract fractions. Conclusion: Viburnum foetidum bark exerts its antidiabetic effect by enhancing insulin secretion by pancreatic cells, increasing glucose uptake by liver cells and enhancing the pancreas functionality thereby increasing serum insulin and serum α-amylase level.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility