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Research Journal of Medicinal Plants
Year: 2015  |  Volume: 9  |  Issue: 4  |  Page No.: 194 - 200

In vitro Cytotoxicity of Gmelina arborea roxb (Gambhari) on HL-60 Cell Lines

Rohit Sahu, Goli Divakar, Kalyani Divakar and Paras Sharma    

Abstract: Gmelina arborea roxb commonly known as ‘Gambhari’ tree, the various parts of the plants are widely used in diarrhoea, anti-pyretic, thirst, anemia, leprosy, ulcers, consumption, strangury and vaginal discharges. We tested the cytotoxic potential of Gmelina arborea roxb in HL-60 cells. Aqueous Extract of Gmelina arborea roxb (AEGA) was tested at the various concentrations 5, 10, 15 and 20 mg in MTT assay, Cell Viability assays and clonogenic assay. Our study shows that AEGA inhibits cell growth and decrease the cell viability. The AEGA inhibits cell proliferation at a dose and time dependent manners measured by MTT assay. The AEGA very significantly decreased the cell viability of HL-60 Cells after 24 and 48 h compared to the control cells. In the semisolid culture, the number of colonies decreased significantly (p<0.01) in a dose-dependent manner. Overall, AEGA has shown a substantial and significant anti cancer activity in all the models. This protective effect might have been mediated by apoptosis mechanisms.

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