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Research Journal of Medicinal Plants
Year: 2012  |  Volume: 6  |  Issue: 4  |  Page No.: 309 - 317

Evaluation of Antioxidant, Antiulcer Activity of 9-beta-methyl-19-norlanosta-5-ene Type Glycosides from Cucumis sativus Seeds

Naresh Singh Gill and Manoj Bali    

Abstract: The 9-beta-methyl-19-norlanosta-5-ene cucurbitane glycoside from Cucumis sativus seeds was evaluated for its antioxidant, antiulcer activity. Isolation was done by simple chromatographic technique. The evaluation of antioxidant activity by 1, 1-diphenyl-1-picrylhydrazyl and hydrogen peroxide method further more it was evaluated for antiulcer activity using pyloric ligation, water immersion and non steroidal anti-inflammatory drug (indomethacin) induced gastric ulcer model. The triterpenoid glycosides showed maximum antioxidant activity i.e., 73.21±3.11 and 71.63±2.51% by 1,1-diphenyl-1-picrylhydrazyl, hydrogen peroxide method at 300 μg mL-1, respectively as compared to ascorbic acid. Further, it was evaluated for anti ulcerogenic activity, the compound showed optimum percentage inhibition i.e., 56.6, 68.5 and 62.6% by pyloric ligation, water immersion stress and non steroidal anti-inflammatory drug (indomethacin) induced ulcer modal at 300 μg mL-1 against ranitidine in rats. Thus, it can be concluded that the isolated triterpenoid glycosides may be responsible for the antioxidant and antiulcer activity.

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