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Research Journal of Medicinal Plants
Year: 2012  |  Volume: 6  |  Issue: 3  |  Page No.: 260 - 266

Anti-fertility Investigation of Butea monosperma (Lam.) Kuntze Root in Female Albino Mice

Surendra Kr. Sharm, Geeta Rai and Neeru Vasudeva    

Abstract: The root of B. monosperma was successively extracted by solvents in increment of polarity. The extracts were administered orally at the dose of 200 mg kg-1 body weight to adult female mice of proven fertility for evaluation of anti-implantation activity. The extracts showing anti-implantation activity were further evaluated at the similar dose for estrogenic and anti-estrogenic activity in immature female mice. Biological and histological studies were also performed. Of the four extracts i.e., petroleum ether, chloroform, methanol and aqueous extracts, petroleum ether and chloroform extracts showed significant anti-implantation activity at dose 200 mg kg-1 body weight. Both these extracts showed anti-estrogenic effect. The weight of ovaries of petroleum ether and chloroform extracts treated animal reduced significantly (p<0.01) as compared to control. This was associated with an elevation in the level of cholesterol. Petroleum ether and chloroform extracts inhibited the activity of G-6-PDH to a significant (p<0.05, p<0.01) extent and thus indicating anti-steroidogenic activity of the extract. It may be concluded that petroleum ether and chloroform extracts possess some estrogen like compounds which may be responsible for anti-estrogenic activity of the extracts.

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