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Research Journal of Medicinal Plants
Year: 2011  |  Volume: 5  |  Issue: 3  |  Page No.: 338 - 342

Local Anesthetic Effect of Citrullus colocynthis on Rana hexadactyla

T. Ramanathan, S. Gurudeeban and K. Satyavani    

Abstract: Local anesthetics are a well-known group of pharmaceutical agents used to relieve pain in specific parts of the organism, inhibiting propagation of signals along the nerves. The present study petroleum ether extract of Citrullus colocynthis was evaluated its local anesthetic activity in the animal frog Rana hexadactyla. Local anesthetics are intended to relieve pain by depressing or blocking the sensory nerves reversibly. Local anaesthetics block nerve conduction where applied locally to nerve tissue in appropriate concentration 1:10 and 1:100. They act on any part of the various systems and on every type of nerve fibre. Lumbar plexus anesthesia method (or) nerve block Anesthesia method is used to study the activity briefly. This study proves that the leaves are equally effective as that of the synthetic standard drug xyclocaine when placed in sciatic nerve. Further studies are warranted to compare the mechanism of action.

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