Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Research Journal of Medicinal Plants
Year: 2011  |  Volume: 5  |  Issue: 2  |  Page No.: 158 - 168

Anti-inflammatory and Antipyretic Effects of an Ethanolic Extract of Capparis erythrocarpos Isert Roots

C. Amaning Danquah, E. Woode, E. Boakye Gyasi, M. Duwiejua and C. Ansah    

Abstract: Capparis erythrocarpos Isert (Caparaceae) is a plant used traditionally in Ghana for the treatment of inflammation, fever and pain. The aim of the study was to assess the activity of an ethanolic extract of Capparis erythrocarpos Isert roots in the carrageenan-induced foot oedema model in chicks, an acute inflammatory model and baker’s yeast-induced pyrexia in rats. Pre-treatment with the extract (10-300 mg kg-1; p.o.) significantly inhibited foot oedema in the chicks with maximal inhibition of 48.86±20.41 %; however, the effect was U-shaped. The reference NSAID used, diclofenac (10-100 mg kg-1, i.p.), dose-dependently reduced the oedema with a maximal effect of 58.77±17.15%. Similarly, the steroidal anti-inflammatory drug, dexamethasone (0.3-3 mg kg-1, i.p.), completely inhibited the oedema produced dose-dependently. The effect of the extract on pyrexia was also appreciable. C. erythrocarpos (30-300 mg kg-1; p.o.), significantly and dose-dependently decreased baker’s yeast induced fever. Paracetamol (10-100 mg kg-1; p.o.), used as the reference drug also dose-dependently decreased baker’s yeast induced pyrexia. In summary, C. erythrocarpos has anti-inflammatory and antipyretic activity and these findings support the use of the extract in traditional medicine for treating inflammatory conditions.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility