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Research Journal of Medicinal Plants

Year: 2009  |  Volume: 3  |  Issue: 3  |  Page No.: 80 - 92

Therapeutic Effect of Telfairia Occidentalis on Protein Energy Malnutrition-Induced Liver Damage

O.T. Kayode, A.A. Kayode and A.A. Odetola

Abstract

Comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in treatment of Protein Energy Malnutrition (PEM) induced liver damage. PEM rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days and then divided into four dietary treatment groups: 2% protein (group A; PEM control group); 20% protein and 10% T. occidentalis (group C); 20% protein (group D) and 10% T. occidentalis (group E). The protein deficient diet caused a significant increase (p<0.01) in hepatic malondialdehyde (MDA) level and the liver function enzymes alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) level in the serum. It also caused a marked reduction (p<0.01) in glutathione level, significant decrease (p<0.01) in the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) and significant damage to the hepatocytes. Recovery diets of protein alone and protein supplemented with T. occidentalis had significant effects on all the parameters. The MDA level and the serum liver function enzymes were significantly reduced (p<0.01), glutathione and antioxidant enzymes levels were markedly increased (p<0.01) and a highly significant hepatocyte healing observed in the histology images. The highest recovery was however observed in group C. Results indicate the restorative ability of T. occidentalis in treatment of oxidative stress induced liver damage in PEM rats.

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