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Research Journal of Medicinal Plants
Year: 2007  |  Volume: 1  |  Issue: 1  |  Page No.: 7 - 12

Antibacterial Activity of Isolated Constituents and Extract of Roots of Inula racemosa

P.D. Lokhande, K.R. Gawai, K.M. Kodam, B.S. Kuchekar, A.R. Chabukswar and S.C. Jagdale    

Abstract: The resistance of different bacteria to the current antibacterial agents, toxicity of the antibacterial agents and the cost of the treatment has led to the development of new active molecules against the bacteria. Since ancient times medicinal plants have been used for the treatment of bacterial infections. The roots of the plant Inula racemosa has been used as folk medicine in East Asia and Europe. However, no systematic data is available on the antibacterial activity profile of the different constituents of Inula racemosa. In the present studies, attempt has been made for isolation of root constituents of Inula racemosa (Compositae) and evaluation of its antibacterial activity. The constituents were isolated and purified by column chromatography. The structure of the isolated constituents were confirmed by spectral analysis and were used for the determination of the antibacterial activity of Inula racemosa against various microorganisms. The constituent alantolactone showed maximum antibacterial activity as compared to other constituents and ethyl acetate extract of the roots.

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