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Research Journal of Medicinal Plants
Year: 2007  |  Volume: 1  |  Issue: 4  |  Page No.: 139 - 143

Effect of Aqueous Nauclea pobeguinii Leaf Extract on Rats Induced with Hepatic Injury

Helen Kadiri, Ese Adegor and Samuel Ogheneovo Asagba    

Abstract: Forty male albino rats (Wistar strain) weighing between 150 and 170 g were used to study the antioxidant property of Nauclea pobeguinii extract. The rats were divided into four groups, each group consisting of 10 animals. The antioxidant activity of the extract was evaluated using CCl4-induced lipid peroxidation model. Group one was kept on normal diet and served as control, the second group received the extract alone three times daily for 10 days by oral route, the third received only CCl4 in olive oil by subcutaneous injection, while the fourth group received the extract at the same dose and duration as group two before exposure to CCl4. Eighteen hours after CCl4 administration, the animals were sacrificed, blood was collected and serum separated for analysis. Biochemical analysis of serum indicate increased activities of L-alanine aminotransferase (L-ALT), L-aspartate aminotransferase (L-AST) and alkaline phosphatase (ALP) in CCl4 administered rats which is an indication of liver damage occassioned by lipid peroxidation. Prior treatment of CCl4 exposed rats with the plant extract lowered the serum activities of these enzymes to levels that were comparable to control. The study indicates that aqueous extract of N. pobeguinii possess antioxidant property since it improves recovery or reduces the toxic effects of CCl4 in liver cells of male rats.

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