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Research Journal of Medicinal Plants
Year: 2007  |  Volume: 1  |  Issue: 4  |  Page No.: 134 - 138

Antidiabetic Effects of Homalium letestui (Flacourtiaceae) in Streptozotocin Induced Diabetic Rats

Jude E. Okokon, Bassey S. Antia and Basil N. Ita    

Abstract: Evaluation of antidiabetic activity of ethanolic root extract of Homalium letestui in rats was carried out. Antidiabetic potentials of the plant Homalium letestui extract (500-1000 mg kg-1) was investigated in streptozotocin induced diabetes in rats. Treatment of streptozotocin diabetic rats with the extract caused a significant (p<0.01) reduction in fasting Blood Glucose Levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide. This results suggest that the root extract of Homalium letestui possesses antidiabetic effect on streptozotocin induced diabetic rat.

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