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Research Journal of Environmental Toxicology
Year: 2011  |  Volume: 5  |  Issue: 2  |  Page No.: 152 - 161

Effect of Diazinon on Acetylcholinesterase Activity and Lipid Peroxidation of Poecilia reticulata

Archana A. Sharbidre, Vimal Metkari and Priyanka Patode    

Abstract: The present study was undertaken to evaluate the toxicity and effects of a commercial formulation of the organophosphorous insecticide, Diazinon on acetylcholinesterase and lipid peroxidation activity in the freshwater guppy fish Poecilia reticulata. The fish exposed for 96 h to 50, 100 and 150 μg L-1 concentrations of diazinon at 24.0±1.0°C. Some characteristics of this aquarium water were dissolved oxygen, 7.2-7.9 mg L-1 and conductivity, 0.212-0.260 mS. Each exposure involved 3 treatments with 3 replicates and 1 control (without diazinon). In each aquarium (Volume: 5 L) were 10 fishes. Induction of oxidative stress in various tissues was evidence by increased lipid peroxidation levels. Acetylcholinesterase activity responded positively in a concentration dependent pattern, thus, suggesting the use of these two parameters as potential biomarkers of toxicity associated with contaminations exposure in freshwater fishes.

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