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Research Journal of Environmental Toxicology
Year: 2008  |  Volume: 2  |  Issue: 1  |  Page No.: 35 - 52

Delayed Effects of Acute Deltamethrin Toxicity on Brain and Blood Monoamines and Free Amino Acids: Therapeutic Role of Selenium-Supplementation

Emad El-Zayat, Sayed Rawi and Nashwa Ismail    

Abstract: The present study was designed to investigate the therapeutic effect of selenium on delayed deltamethrin (DM) neurotoxicity. Animals under investigation were treated with a single acute dose of deltamethrin (¼ LD50 = 111.25 mg/100 g body weight). The therapeutic effect of selenium has been evaluated by administration of a daily dose either individually or in antioxidant preparation (Antox) for a period of three weeks. Acute deltamethrin intoxication induced marked alterations in the brain and blood levels of monoamines and free amino acids as well as acetylcholinesterase activity. Selenium supplementation, either individually (DMS) or in antioxidant preparation (DMA), showed a considerable ability to attenuate some but not all signs of delayed deltamethrin neurotoxicity. Among the two Se-supplemented groups, it was difficult to see a clear therapeutic effect on all measured parameters. DMS showed the best results in some cases but DMA showed the best results in others reflecting different mechanisms of action. These therapeutic effects seemed to be time-dependent.

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