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Research Journal of Environmental Sciences
Year: 2014  |  Volume: 8  |  Issue: 3  |  Page No.: 142 - 148

Sub-chronic Toxicity Assessment of Local Textile ‘Adire and Kampala’ (Tie and Dye) Effluents on Mice (Mus musculus)

A.M. Oloyede, O. Ogunlaja and A. Ogunlaja    

Abstract: ‘Adire and Kampala’ (Tie and dye) have been produced in Itoku, Abeokuta, Ogun state-Nigeria for over a century. Large quantity of water has been involved and effluents have been discharged into surrounding sources of water without adequate treatment. The evaluation of the sub-chronic toxicity of the Adire and Kampala textile effluents is done by investigating its effect on the weights, histopathologic and haematologic indices in normal albino mice. Normal albino mice of either sex weighing between 23 and 37 g were divided into five groups of 10 animals each. Four concentrations were orally administered 1, 5, 25 and 50% while control animals received distilled water over 28 days. Animals were weighed weekly and sacrificed after day 28. Organs were harvested, weighed and subjected to histopathologic assessment. Blood samples were used for haematological studies. The 30 and 50% mortality was observed in the groups administered 25 and 50% concentration, respectively and several signs of toxicity were observed in other groups. Decreased organs and body weight, WBC, PCV and Hb significantly different from control were observed. Histopathologic studies showed remarkable distortion in the histo-architecture of the visceral organs, like alveoli disruption, spleen pigmentation, tubular necrosis in kidney and hemorrhage in the heart. The mortality observed, decreased haematologic indices, internal organs, body weight and gross distortion in the histo-architecture of the visceral organs are indications that the ‘Adire and Kampala’ textile effluents contain substances that are toxic to the animal physiology. These substances which may have seeped into surrounding rivers and wells in Abeokuta town can cause severe health malaise in the inhabitants of such area.

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