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Research Journal of Biological Sciences
Year: 2013  |  Volume: 8  |  Issue: 5  |  Page No.: 150 - 154

Lipid Lowering Activity of Moringa pergerina Seeds in Rat: A Comparison Between the Extract and Atorvastatin

Hojjat Rouhi-Broujeni, Esfandiar Heidarian, Pariya Darvishzadeh-Boroojeni, Mahmoud Rafieian-Kopaei and Mojgan Gharipour    

Abstract: Hyperlipidemia is the most important cardiovascular risk factor. Moringa peregrina is traditionally used as antihyperglycemia and antihyperlipidemia. This study aimed to investigate, the effects of hydroalcoholic extract of Moringa peregrina on lipid profile and atherogenic biomarkers of hyperlipidemic rat. In this experimental study, 40 male Wistar rats were divided into four equal groups: Normal rats, high fat diet rats (hyperlipidemia induced with persintra-M) high fat diet with Moringa peregrina, high fat diet plus atorvastatin. The regimens were given orally (by gavage) for 40 days. Also, serum lipid profile, thiol level, Malondyaldehide (MDA), antioxidant capacity, ferritin, CRP as well as atherogenic index were determined. Treatment with Moringa peregrina seeds significantly decreased serum LDL, VLDL, trigeliceride and total cholesterol and increased HDL-C. The Atherogenic index decreased. Also, MDA, ferritin and CRP were reduced and plasma thiol level icreased. The data demonstrates that the leaves ethanolic extract of Morninga peregrina has antioxidant activity and antilipidemic effect on hyperlipidemic rats. Also, reduction of lipid and protein peroxidation as an index of oxidative stress is evident.

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