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Research Journal of Biological Sciences
Year: 2011  |  Volume: 6  |  Issue: 2  |  Page No.: 55 - 57

Cytotoxic Activity of Lythrum salicaria L.

Mahnaz Khanavi, Mana Moshteh, Azadeh Manayi, Mohamad Reza Shams Ardekani, Mahdi Vazirian, Yousef Ajani and Seyed Nasser Ostad    

Abstract: The aerial parts of Lythrum salicaria L. from Lahijan in Gillan province have been collected in June 2009. Total extract were obtained by MeOH/H2O (80/20) and then partitioned between CHCl3, EtOAc and MeOH. These fractions and total extract have been investigated for in vitro cytotoxic activity against colon carcinoma (HT-29), lukemia (K562), breast ductal carcinoma (T47D) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT assay (3-(4,5-di methyl thiazol-2-yl)-2,5-di phenyltetrazolium bromide). At each cell line doses of 50, 100, 200, 400 and 800 μg mL-1 in 1% (v/v) DMSO of all samples were tested. Ethyl acetate fraction against proliferation of T47D cell line has been represented high cytotoxic activity (IC50<70). Chloroform fraction and total extract against proliferation of T47D cell line and chloroform fraction toward K562 cell line and total extract against HT-29 cell line have been demonstrated slightly cytotoxic activity (IC50<200). The other fractions have been demonstrated no effective cytotoxic activity. IC50 values confirmed that the growth and proliferation of T47D cells were most affected by ethyl acetate fraction.

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