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Research Journal of Biological Sciences
Year: 2011  |  Volume: 6  |  Issue: 10  |  Page No.: 547 - 549

The Effect of Hydro-alcoholic Extract of Grape Seed (Vitis vinifera) on Sugar and Lipids in Serum of Diabetic Rats

Vahid Rostamian, Farzaneh Shakeri and Jasem Estakhr    

Abstract: Now-a-days, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. This study aimed at assessing the effect of grape seed extract on the blood glucose and lipid profile in diabetic rats. A total of 30 male adult rats were randomly selected and divided into 3 groups as; non-diabetic control, diabetic control and diabetic rats treated with hydroalcoholic extract of grape seed. In diabetic groups, alloxan monohydrate (120 mg kg-1) was injected intraperitoneally to develop diabetes. Then the test group received intraperitoneal injection of hydro-alcoholic extract of grape seed (100 mg kg-1). At last, glucose, cholesterol, triglyceride, HDL, VLDL, LDL and insulin contents of the rats' serum sample were determined. Diabetic rats treated with extract showed a significant decrease in blood glucose level (p<0.05). Furthermore, compared diabetic group, in the extract-treated rats, there was a significant decrease in serum contents of Total Cholesterol (TC), LDL, VLDL and TG but a significant increase in insulin level and HDL (p<0.05). These results show that the hydroalcoholic extract of grape seed may be effective in the treatment of diabetes. This effect can be due to the presence of flavonoides and their antioxidant features.

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