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Research Journal of Biological Sciences
Year: 2009  |  Volume: 4  |  Issue: 5  |  Page No.: 580 - 584

Antibacterial Effect of Gracilaria changii and Euchema denticulatum on Molecular Properties of Staphylococcus aureus Genes mecA, mecR1 and mecI

Nagi A. AL-Haj, Nurmas I. Mashan, Mariana N. Shamsudin, Habsah Mohamad, Charles S. Vairappan and Zamberi Sekawi    

Abstract: Gram-positive bacteria are more sensitive to antibiotics than gram-negative bacilli because of the lack of outer membrane which prevent easy access of the drug into the bacterial cells. However, there are many gram-positive organisms with natural, intrinsic resistance to antimicrobials. In addition, these bacteria are able to acquire resistance to frequently used drugs rapidly through selective pressure of the environment and also via the genetic evolution of bacteria. The resistance of those bacteria to antibacterial agents is mediated by antibiotic resistant genes. Therefore, the current study was designed to explore the effect of seaweed extracts on several antibiotic resistant genes in Staphylococcus aureus mec genes mecA, mecR1 and mecI that regulate the expression of methicillin resistance was investigated by PCR.

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