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Research Journal of Biological Sciences
Year: 2008  |  Volume: 3  |  Issue: 11  |  Page No.: 1271 - 1275

Effect of Dietary Taurine on Lipid Profile and Oxidative Stress in Tissues of Homocystein-Treated Rats

Zakaria Vahabzade, Aliakbar Abolfathi, Mohammadhasan K. Ansari and Abdolrasul Safaiyan    

Abstract: It has been suggested that taurine as intracellular non-protein amino acid has hypolipidemic and antiatherosclerotic effects. To study the beneficial effect of taurine on serum lipids and markers of oxidative stress in tissues of rats treated with low oral dose of Homocysteinethiolacton hydrochloride, 32 Male adult Wistar rats of body weight 21212 g were divided in to the 4 groups consisting of 8 rats each i.e., Control, Control + Homocysteine, Control + Taurine and Control + Homocysteine + Taurine, for a 6 weeks period. Food intake, fluid intake and body weight changes were monitored weekly. At the end of the experimental period, the rats were anesthetized, plasma was collected by direct cardiac puncture in heparinated tube and were used for measurement of HDL-C, LDL-C, total cholesterol, triglyceride (TG) and total antioxidant capacity. The heart and kidney were removed immediately and homogenized in phosphate-buffered saline (pH 7.4). Supernatants were separated in tree aliquots; Glutathione peroxidase (GPX), superoxide dismutase (SOD) and malondialdehayde (MDA) were measured in tissue homogenate supernatants. There were no significantly differences in lipid profile of homocystein-treated rats with control rats and other experimental groups. The levels of MDA of Control+Homocysteine rats were significantly higher in compare with Control + Taurine group. The activity of SOD in Control + Homocysteine group, were significantly lower in compare to rats received 2% taurine in Control + Taurine group. In conclusion, increase in TG and MDA levels and decrease in SOD activity of rats treated with Homocysteine were observed and beneficial effect of taurine in treated rats in our study are obvious.

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