Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Research Journal of Biological Sciences
Year: 2006  |  Volume: 1  |  Issue: 1  |  Page No.: 12 - 15

CTLH: A Novel Domain with A Typical "U" Shape Architecture

Weiqi Zeng, Yuequn Wang, Wuzhou Yuan, Yun Deng, Yongqing Li, Chuanbing Zhu, Mingyao Liu and Xiushan Wu    

Abstract: We described here a novel domain, CTLH, which can be found in proteins of most already-researched species currently. The domain, consisted of 58 amino acid residues, is not often-conserved in sequence (but has 5 regularly-arranged leucines that are highly conserved). However, its 3D architecture conserves greatly with a typical ŽUŽ shape (alpha helix+beta turn+alpha helix). Although the function of CTLH domain remains unknown, related studies aiming at this domain suggest it participates in the regulation of certain signaling pathways like MAPK, and is involved in some living activities of cells such as protein degradation and mitosis.

Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility