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Research Journal of Botany
Year: 2011  |  Volume: 6  |  Issue: 1  |  Page No.: 11 - 20

Antioxidant Activity and Biological Evaluation of Hot-water Extract of Artemisia monosperma and Capparis spinosa Against Lead Contamination

A. Al-Soqeer    

Abstract: Hot-water extracts of Capparis spinosa and Artemisia monosperma were studied against lipid peroxidation induced by lead acetate in rats. Ten rats were assigned to each of four groups. Group 1 was negative control, group 2 received only lead acetate (0.6%) in drinking water (positive control), group 3 received hot-water extract from Artemisia (5%) with lead acetate in drinking water (0.6%) and group 4 received hot-water extract from Capparis (5%) with lead acetate in drinking water (0.6%) experiment continued for 6 weeks before scarifying the animals and blood samples were collected. Chemical composition and antioxidant activities of hot-water extract from Artemisia and Capparis sp. were estimated using chemical methods. Total Antioxidants in Artemisia and Capparis extracts were 675.33, 115.66 μmol Trolox per 100 mL, respectively. Activity of the antioxidant enzyme glutathione-S-transferase activity decreased after lead administration but extracts from Artemisia and Capparis maintained the level to normal. Lead administration resulted in significant increases in the concentration of serum triglycerides, urea and aspartate transaminase, alanine transaminase (AST and ALT). Extracts from Artemisia and Capparis reduced the elevated concentrations to normal values. The obtained results showed that the biochemical alterations produced by lipid peroxidation after lead administration returned to normal values or even improved due to high levels of total antioxidants in extracts of Artemisia and Capparis sp. Data concluded that the protective effects of hot-water extracts from Artemisia and Capparis sp. may play a role in protection against lead acetate in rats. This protective effect may be due to high level of total antioxidant contents in these plants.

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